Case Studies

With over 15 years’ experience,Charnwood Molecular has helped many of our clients achieve their goals in both a cost-effective and timely manner across a huge range of projects and programmes.

The case studies outlined below highlight just some of our more recent collaborations:

Pharma (multinational, UK-based)

pharma(multinational,uk-based

  • 3 FTE Chemists for 3 years
  • Extension to pharma’s project team
  • Synthesis of novel active materials as part of specific medicinal chemistry project
  • Diverse chemistries to individual materials & small focussed libraries often involving significant problem solving by Charnwood Molecular
  • Novel targets designed in collaboration with client, Charnwood Molecular designed and implemented synthetic routes
  • Materials assayed by Pharma
  • 50mg samples supplied, bar-coded vials, 1H NMR & LCMS, SD files supplied
  • Weekly reporting, customer LNB’s/ numbering/ packaging
  • Reports & experimental documented at customers request
  • Customer visit every 3 months

Pharma (multinational, EU-based)

pharma(multinational,eu-based

  • 3 FTE Chemists for 1 year
  • Medicinal Chemistry project: Design and synthesis of molecules for the treatment of Rheumatoid Arthritis (RA)
  • Involved at Lead Optimisation stage looking for compounds with the correct balance of potency/selectivity/physicochemical properties to progress to in vivo arthritis models and potentially further
  • Combination of singleton and parallel chemistry to facilitate rapid project progress
  • Flexible/rapid sharing of information via client confidential e-rooms and teleconferences
  • Charnwood Molecular seen as extension of in house project team by solving synthetic/medicinal chemistry problems in the series and offering medicinal chemistry ideas to client Project Leader
  • Project resourced further in-house by client after Charnwood Molecular’s successful involvement
  • Client poster featured at major EU conference

Biotechs (EU)

Biotechs (EU)

  • Average 6 month FTEs
  • Three way collaboration: CM, CADS, Customer Assay
  • Synthesis of analogues to: Explore SAR to Identify new ligand types, followed by:
  1. Programme agreement
  2. First molecules designed
  3. Molecules synthesised
  4. Samples assayed
  • Synthesis of novel active materials as part of specific Medicinal Chemistry project
  • 50mg samples, C of A / MSDS, 1H NMR, LCMS
  • Weekly reporting, Charnwood Molecular completes LNB’s/ numbering/ packaging
  • Teleconference monthly, after initial face-to-face meeting

Medical Research Institutes (US-based)

Medical Research Institutes (US-based)

  • 2 FTE Chemists for 1 year
  • Lead optimisation antiviral project
  • Route development to allow rapid access to diverse range of final medicinal chemistry analogues
  • Small focused libraries made to allow rapid project progress
  • Sharing of biological data to enable Charnwood Molecular to provide medicinal chemistry input
  • Target designs synthetically enabled from our extensive experience in the pharma industry
  • Weekly client updates

Biotech (UK-based)

Biotech (UK-based)

  • Rolling FTE contract (2 month blocks, 2 chemists)
  • Patent expansion and customer assay
  • Small focussed libraries
  • Larger matrix (>100 cmpds)
  • Materials supplied in multiple formats to several global client research sites
  • Weekly updates & teleconference
  • Feedback to customer to assist in-house projects