To enable this, the Charnwood Molecular PR&D group has on-site access to state-of-art equipment including:
• Radleys Lara reactor system, 1-10L (for control key reaction scale-up parameters)
• Mettler Toledo DSC3 (for safety and stability testing)
• Mettler Toledo Karl-Fischer V10S system (for water content determinations of intermediates and final products)
• Technobis Crystal 16 benchtop crystallisation system (for crystallisation screens – salt forms/polymorphs – and solubility determinations)
As most Development activities are dependent on an adequate supply of API, it is important to keep the Chemical Development activities a phase ahead of the requirements of other departments. Although initial quantities of the API provide the fuel for the Development engine, ultimately, it is the quality of the manufacturing process that will be the most valuable output from the PR&D effort. Chemistry problems are solved more efﬁciently and economically in the laboratory rather than on plant, where costs increase 15-fold.
Effective PR&D saves time and costs in New Product Development. Inefﬁcient chemistry can cost a project up to 18 months in time, negatively impacting New Product Value (NPV) by up to 30%. The 20-50kg campaign is often the real rate-limiting delivery stage, with a major impact on NPV. This needs to be considered early and Charnwood Molecular’s PR&D group can help you do this.
Please contact us directly if you have a project which might benefit from our involvement.
More information on our Chemical Development expertise can be found here:
Charnwood Molecular – Chemical Development Expertise