Facilities

In 2003 Charnwood Molecular relocated from Loughborough University into premises containing three newly refurbished laboratories, fully equipped for carrying out research chemistry.

In 2012, to serve the growing demand for our medicinal chemistry services, we expanded into an additional state-of-the-art research facility within BioCity, Nottingham. Here, our experienced medicinal chemists (including ex Pfizer and AstraZeneca personnel who have previously helped to deliver multiple small molecules into phase 2 trials) undertake our clients’ Lead Finding and Lead Optimisation programs to rigorous standards.

Our specialised equipment includes:

For Single Compound Synthesis

• Reactors up to 20 litre capacity operating from –78 to +200 ° C
• Buchi BEP280 autoclave system working up to 12 bar
• CEM microwave synthesis system
• Fisher Ozone Generator
• Miniclave 50mL/300mL at 10 bar
• Parr 50-300mL steel autoclaves
• Rayonet RMR-200 Photochemical Reactor

For Parallel Synthesis/Evaporation/Purification

• Radleys Carousel Reactors
• Radleys and STEM Parallel Synthesis Systems
• Genevac DD4
• Isco Sq 16x Open Access Purification System
• Waters Mass Directed Prep LCMS System
• Buchi flash chromatography system – up to 2 Kg stationary phase
• Biotage Isolera 4 purification systems
• Edwards freeze drying apparatus

Analytical Equipment

• High field NMR spectrometers (400 MHz)
• Applied Biosystems API 150EX LCMS
• Gilson preparative/analytical HPLC
• GCMS, HPLC (including chiral analysis)
• Elemental analysis
• FT-IR spectroscopy