Journal Publications

Work involving Charnwood Molecular’s chemistry team has seen regular publication in the peer-reviewed scientific and patent literature:

Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity – P. Johansson, K. Kaspersson, I.K. Gurrell, E. Back, S. Eketja, Clay W. Scott, G. Cebers, P. Thorne, M. J. McKenzie, H. Beaton, P. Davey, K. Kolmodin, J. Holenz, M.E. Duggan, S. Budd Haeberlein, and R.W. Burli, J. Med. Chem. 2018, 61, 3491.

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b01716

New 4-Aryl-1,3,2-oxathiazolylium-5-olates: Chemical Synthesis and Photochemical Stability of a Novel Series of S-Nitrosothiols – M.E. Richardson, S.M. Allin, R.J. Pearson, Bioorg. Med. Chem. Lett., 2018, 28, 1106.

https://www.sciencedirect.com/science/article/pii/S0960894X18300702

Formal Total Synthesis of (+)-C9-Deoxyomuralide from L-Leucine Using a Double Sacrificial Chirality Transfer Approach – P.C.B Page, R.L. Goodyear, A.E. Horton, Y. Chan, R. Karim, M.A. O’Connell, C. Hamilton, A.M.Z. Slawin, B.R. Buckley, S.M. Allin, J. Org. Chem. 2017, 82, 12209.

http://pubs.acs.org/doi/10.1021/acs.joc.7b02078

New Biphenyl Iminium Salt Catalysts for Highly Enantioselective
Asymmetric Epoxidation: Role of Additional Substitution and Dihedral
Angle – P.C.B. Page, C.J. Bartlett, Y. Chan, G.A. Jones, S.M. Allin, M.J. McKenzie, J. Lacour, R. Novikov, Organic & Biomolecular Chemistry, 2016, 14, 4220 – 4232

http://pubs.rsc.org/en/content/articlelanding/2016/ob/c6ob00542j#!divAbstract

A Dendrimer Conjugate of 4-(Tetradecanoylamino)benzyl]phosphonic Acid (S32826) as an Autotaxin Inhibitor – N. Fisher, T. Hilton-Bolt, M.G. Edwards, K. Haxton, M.J. McKenzie, S.M. Allin and A. Richardson, ACS Med. Chem. Lett, 2014, 5, 34.

http://pubs.acs.org/doi/10.1021/ml4003106

Kinetic Resolution in Asymmetric Epoxidation using Iminium Salt Catalysis -
P.C.B. Page, L. Appleby, Y. Chan, D. Day, B. Buckley, A.M.Z. Slawin, S.M. Allin, M.J. McKenzie, J. Org. Chem, 2013, 78, 8074.

http://pubs.acs.org/doi/10.1021/jo401345m

Enantioselective Total Synthesis of (+)-Scuteflorin A Using Organocatalytic Asymmetric Epoxidation – C.J. Bartlett, Y. Chan, D. Day, S.M. Allin, M.J. Mckenzie, A.M.Z. Slawin and P.C.B. Page, J. Org. Chem, 2012, 77, 772.

http://pubs.acs.org/doi/10.1021/jo2021407

Enolate Amination and Derivatization of a Pyrroloisoquinoline Template: Towards Novel Peptidomimetics – S.M Allin, S.N Gaskell, J.M.R. Towler, P.C.B Page, Tetrahedron, 2010, 66, 9538.

https://www.sciencedirect.com/science/article/pii/S0040402010014973

Facile Asymmetric Construction of a Functionalized Dodecahydrobenz[a]indolo[3,2-h]quinolizine: Towards the Manadomanzamine Alkaloids – S.M. Allin, L.J. Duffy, J.M.R. Towler, P.C.B. Page, M.R.J. Elsegood and B. Saha, Tetrahedron, 2009, 65, 10230.

https://www.sciencedirect.com/science/article/pii/S0040402009014689

Highly Enantioselective Total Synthesis of (-)-(3’S)-Lomatin and (+)-(3’S, 4’R)-trans-Khellactone – P.C,B. Page, L.F. Appleby, D. Day, Y. Chan, B.R. Buckley, S.M. Allin and M.J. Mckenzie, Org. Lett, 2009, 11, 1991.

http://pubs.acs.org/doi/pdf/10.1021/ol900444h

A New Asymmetric Synthesis of the Anti-tumour Alkaloid Crispine A – S.M. Allin, S.N. Gaskell, J.M.R. Towler, P.C.B. Page, B. Saha, M.J. Mckenzie and W.P. Martin, J. Org. Chem., 2007, 72, 8972.

http://pubs.acs.org/doi/abs/10.1021/jo071235x

In Situ Generation of o-Iodoxybenzoic Acid (IBX) in the Presence of Tetraphenylphosphonium Monoperoxysulfate (TPPP) for the Conversion of Primary Alcohols into the Corresponding Aldehydes – P.C.B. Page, L. Appleby and S.M. Allin, Synlett, 2007, 1565.

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-982550

Novel Polymer-bound Aminoalcohol Ligands for the Asymmetric Addition of Diethylzinc to Aldehydes – P.C.B. Page, S.M. Allin, S.J. Maddocks and B.R. Buckley, Synth. Commun., 2007, 37, 2019.

http://www.tandfonline.com/doi/full/10.1080/00397910701356553

Towards a Total Synthesis of the Manadomanzamine Alkaloids: The First Asymmetric Construction of the Pentacyclic Indole Core – S.M. Allin, L.J. Duffy, M.R.J. Elsegood, and P.C.B. Page, Tetrahedron Lett., 2007, 48, 4711.

https://www.sciencedirect.com/science/article/pii/S004040390700874X

A Short Preparation of an Advanced Intermediate for Lactacystin Synthesis: The Complete Carbon Skeleton of Clasto-Lactacystin Dihydroxyacid – P.C.B. Page, D.C. Leach, C.M. Hayman, A. Sazali Hamzah, S.M. Allin, V. McKee, Synlett, 2003, 1025.

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2003-39290

A Short and Versatile Route to a Key Intermediate for Lactacystin Synthesis – P.C.B. Page, A. Sazali Hamzah, D.C. Leach, S.M. Allin, D.M. Andrews, G. A. Rassias, Org. Letts, 2003, 5, 353.

http://pubs.acs.org/doi/10.1021/ol027387q

New Ligands for Asymmetric Diethylzinc Additions to Aromatic Aldehydes, Demonstrating Substrate-Dependent Non-linear Effects – P.C.B. Page, S.M. Allin and S.J. Maddocks, Perkin Trans 1, 2002, 2827.

http://pubs.rsc.org/en/content/articlelanding/2002/p1/b208810j#!divAbstract