Medicinal Chemistry: Hit-to-Lead (H2L) (#1)

Medicinal Chemistry Hit-to-Lead (H2L)

• UK Biotech company (Immuno-oncology target)
• Supported with 4 FTEs for 12 months
• Synthetic and medicinal chemistry expertise provided
• Biology provided by Xenogesis (cell and DMPK assays)
• Elaboration of existing hits to elucidate SAR
• Rational design to deliver druglike compounds
• >300 compounds prepared over three series
• Highly potent compounds with good ADME properties and clear SAR

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