Medicinal Chemistry: Lead Optimisation (LO)

Medicinal Chemistry Lead Optimisation (LO)

• US Biotech company (Oncology target)
• Supported by up to 6 FTEs for 18 months
• Elaboration of existing hits to elucidate SAR
• Rational design to deliver drug-like compounds
• Compounds screened by client (biochemical assays)
• >80 compounds prepared over numerous series
• Highly potent compounds with good ADME properties, clear SAR and in vivo efficacy
• Route scouting and route optimisation for a lead candidate and technical transfer to a North American GMP manufacturer

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