Charnwood Molecular in the news – Medicine Maker article

Charnwood Molecular

In case you missed it, in an interview with The Medicine Maker towards the end of last year, our Head of Medicinal Chemistry, James Hitchin, discussed many of our key considerations and aspirations as a growing CRO collaborating with international clients on Drug Discovery projects:

On the Clear Benefits of Working With Us: we have an ability to “follow up discoveries quickly…allowing greater flexibility and cost savings and focus more on the added value propositions of outsourcing partnerships.”

On the Importance of Staff Development: “supporting the skills required for drug discovery for the next generation of scientists coming through.”

On Compound Selection: “it’s crucial to make good choices at the beginning of the process and pick a candidate that has the potential to go all the way.”

On Compound Optimisation: “you have to really understand your compound and be able to juggle parameters in a way that allows you to produce something that is well tolerated by the body, is rapidly absorbed and goes directly to where you want it to be and then stays there long enough to elicit the desired effect.”

On the Synthetic Challenge: “some of the best compounds can be the most difficult to synthesise…if you spend a bit more time figuring out the challenges in synthesis, you could ultimately end up with something more interesting not only in terms of its medicinal chemistry properties, but also more amenable to process scale chemistry.”

On What Success Looks like: “to eventually deliver compounds that will have the intended effect in a clinical setting (line of sight to the clinic).”

Link to article:
The Medicinal Chemistry Puzzle: Lessons Learned with James Hitchin

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